COMMAS

A 0.2% Chlorhexidine mouthwash prior to anaesthesia in patients undergoing major open elective abdominal surgery to reduce pneumonia within 30 days (COMMAS Trial)

A pragmatic, multicentre, observer blinded, randomised controlled study, COMMAS will provide comprehensive evidence on the effectiveness of a single 0.2% chlorhexidine mouthwash, administered prior to anaesthesia, on the recovery of patients following major abdominal surgery. It will compare this treatment to usual care in 6000 patients across 50 UK hospitals.

The study’s primary objective is to establish if a single 0.2& chlorhexidine mouthwash, administered prior to anaesthesia, compared to standard care, reduce pneumonia by discharge or within 7 days following elective open abdominal surgery for benign & malignant disease. Secondary objectives will determine whether the intervention reduces mortality, other forms of postoperative morbidity, improves quality of life and is cost-effective.


  • Chief Investigator: Mr Ravinder Vohra, Trent Oesophagogastric Unit, Nottingham University Hospitals
  • Interested in this trial? Contact us.